repairon healing hearts cells
repairon healing hearts
repairon healing hearts

Our Company 

Profile

repairon healing hearts shortlogo
repairon healing hearts

Repairon was founded in 2014 on the pioneering work of Prof Wolfram Zimmermann and his team, who have developed several tissue engineering technologies with documented applicability in organ repair.

 

Related intellectual property was exclusively licensed by Repairon to allow the commercialization of Repairon’s innovative tissue engineered products. 

With its first financing in 2017, Repairon was able to enter into a strong strategic partnership with the Medical School in Göttingen and the German Center for Cardiovascular Research. Through this public/private partnership it was possible to take the lead therapeutic product (engineered human myocardium, EHM) from the R&D stage through pre-clinical characterization into clinical development and to establish a solid basis for commercial product development. 

Value
Generation
Steps

  1. A strong IP position for enabling platform technologies – EHM Patch and Pouch (contractile, paracrine), 3-D processing, hypo-immunogenic tissues.
     

  2. Strong data for safety, feasibility and function from pre-clinical models.
     

  3. GMP manufacturing authorization for EHM investigational medicinal products.
     

  4. First registered clinical trial on sustainable remuscularization in heart failure by cardiomyocyte implantation approved and running: BioVAT-HF trial – Ventricular Assist Tissue for Heart Failure
     

  5. A fully characterized iPSC-line with freedom to operate for commercial use.
     

  6. Proof-of-concept for the generation of hypo-immunogenic tissues from a proprietary genetically tailored iPSC line.
     

  7. Process scale-up towards commercial product supply.

With Repairon's lead product entering clinical development and the achievement of important milestones for commercialization, Repairon has successfully arrived at an important value inflection point.